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One mechanism involves reducing transforming growth factor beta-1 secretion in fibroblasts

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“Tesofensine produced weight loss significantly greater than placebo and was more effective than any currently approved obesity drug at the time.” — Astrup et al., The Lancet Additional Findings: → The majority of weight loss came from visceral fat and abdominal adiposity → Lean body mass was preserved , unlike with most appetite suppressants → Participants reported reduced hunger and better diet adherence → Tesofensine significantly improved waist circumference , lipid profiles, and fasting glucose These findings have led to continued interest in Tesofensine’s use for body recomposition — not just for general weight loss, but for fat-specific reduction without muscle sacrifice